A group of researchers supported by the São Paulo Research Foundation in Brazil found that EGCG, a polyphenol present in green tea, inhibits in vitro the entry of a Brazilian strain of the Zika virus into host cells.
EGCG, a polyphenol present in green tea has been shown to have an antiviral activity for many viruses. In view of the need for the development of a drug against a Brazilian strain of ZIKV, we assessed the effect of EGCG on ZIKV entry in Vero E6 cells. The drug was capable of inhibiting the virus entry by at least 1-log (>90%) at higher concentrations (>100μM). The pre-treatment of cells with EGCG did not show any effect on virus attachment.